It’s time to look at creatine through yet another lens. Originally heralded as a supplement to use for muscle building and athletic performance then brain health and now, its potential benefits for traumatic brain injuries (TBI’s).

TBI’s can result from an external mechanical force causing brain dysfunction, are common in athletes who participate in contact sports. The impact of TBI ranges from mild concussions to severe brain damage, often leading to long-term neurological deficits. There has been some exciting new research that has been looking at various treatments using creatine to mitigate the effects of TBI’s.

Creatine's role in energy metabolism makes it an intriguing option for brain health. The brain, like muscles, requires significant energy, especially after an injury. TBI can disrupt cellular energy production, leading to cell death and impaired brain function. By supporting ATP production, creatine may help maintain energy levels in brain cells, promoting recovery and reducing damage.

Here are 4 potential benefits of creatine for TBI’s:

1. Neuroprotection:

   • Creatine has shown potential in protecting brain cells from oxidative stress and apoptosis (programmed cell death). This is crucial after TBI, where oxidative stress and inflammation contribute significantly to brain damage.

2. Cognitive Function:

   • Studies indicate that creatine supplementation may improve cognitive functions such as memory, attention and processing speed in athletes with TBI's. By enhancing energy availability in the brain, creatine can help support cognitive processes that are often impaired after injury.

3. Mitochondrial Function:

   • TBI's often leads to mitochondrial dysfunction, impairing energy production. Creatine helps stabilize mitochondrial membranes and supports their function, potentially reducing secondary brain damage post-injury.

4. Reduction of Secondary Injury:

   • Secondary injury mechanisms, including inflammation and energy failure, exacerbate TBI's initial impact. Creatine's anti-inflammatory properties and ability to sustain cellular energy may help mitigate these secondary injuries, aiding overall recovery.

The preliminary research is promising but of course, more extensive clinical trials are needed to establish standardized dosing protocols and confirm long-term benefits and safety. Scientists are optimistic that creatine supplementation could become an adjunct therapy for TBI’s. 

For more information about this new, emerging research on creatine and TBI’s, refer to the link below to read a recent research article on the topic or reach out to one of the eNRG Performance Sport Dietitians if you would like to schedule a consultation for customized supplementation plans.

Article:

Candow, D.G., Forbes, S.C., Ostojic, S.M. et al. “Heads Up” for Creatine Supplementation and its Potential Applications for Brain Health and Function. Sports Med 53 (Suppl 1), 49–65 (2023). https://doi.org/10.1007/s40279-023-01870-9